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BBC Correspondent Tom
Mangold travelled to Africa and sampled the appetite suppressing Hoodia,
a plant which may make Kalahari bushmen millionaires.
By
Tom Mangold
BBC
Correspondent
 Hoodia
Sampling the Kalahari cactus diet
Imagine this: an organic pill that kills
the appetite and attacks obesity.
It has no known side-effects, and
contains a molecule that fools your brain into believing you are full.
Deep inside the African Kalahari
desert, grows an ugly cactus-like plant called the Hoodia. It thrives in
extremely high temperatures, and takes years to mature.
The
San bushmen have eaten the plant for years
The San Bushmen of the Kalahari, one of
the world's oldest and most primitive tribes, had been eating the Hoodia
for thousands of years, to stave off hunger during long hunting trips.
When South African scientists were
routinely testing it, they discovered the plant contained a previously
unknown molecule, which has since been christened P57.
The license was sold to a
Cambridgeshire bio-pharmaceutical company, Phytopharm, who in turn sold
the development and marketing rights to the giant Pfizer Corporation.
Fortune cactus
A molecule in the cactus makes
you feel full
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When I traveled to the Kalahari, I met
families of the San bushmen.
It is a sad, impoverished and displaced
tribe, still unaware they are sitting on top of a goldmine.
But if the Hoodia works, the 100,000
San strung along the edge of the Kalahari will become overnight
millionaires on royalties negotiated by their South African lawyer Roger
Chennells.
And they will need all the help they
can to secure the money.
Currently, many bushmen smoke large
quantities of marijuana, suffer from alcoholism, and have neither
possessions nor any sense of the value of money.
The truth is no-one has fully grasped
what the magic molecule means for their counterparts in the developed
world.
Blood sugar
According to the British Heart
Foundation 17% of men and 21% of women are obese, while 46% of men and
32% of women are overweight.
So the drug's marketing potential
speaks for itself.
Phytopharm's Dr Richard Dixey explained
how P.57 actually works:
"There is a part of your brain,
the hypothalamus. Within that mid-brain there are nerve cells that sense
glucose sugar.
"When you eat, blood sugar goes up
because of the food, these cells start firing and now you are full.
"What the Hoodia seems to contain
is a molecule that is about 10,000 times as active as glucose.
"It goes to the mid-brain and
actually makes those nerve cells fire as if you were full. But you have
not eaten. Nor do you want to."
Clinical trials
Dixey organised the first animal trials
for Hoodia. Rats, a species that will eat literally anything, stopped
eating completely.
When the first human clinical trial was
conducted, a morbidly obese group of people were placed in a "phase
1 unit", a place as close to prison as it gets.
All the volunteers could do all day was
read papers, watch television, and eat.
Half were given Hoodia, half placebo.
Fifteen days later, the Hoodia group had reduced their calorie intake by
1000 a day.
It was a stunning success.
The cactus test
In order to see for ourselves, we drove
into the desert, four hours north of Capetown in search of the cactus.
Once there, we found an unattractive
plant which sprouts about 10 tentacles, and is the size of a long
cucumber.
Each tentacle is covered in spikes
which need to be carefully peeled.
The San will finally throw off thousands of years of
oppression, poverty, social isolation and discrimination
Roger Chennells, lawyer
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Inside is a slightly
unpleasant-tasting, fleshy plant.
At about 1800hrs I ate about half a
banana size - and later so did my cameraman.
Soon after, we began the four hour
drive back to Capetown.
The plant is said to have a feel-good
almost aphrodisiac quality, and I have to say, we felt good.
But more significantly, we did not even
think about food. Our brains really were telling us we were full. It was
a magnificent deception.
Dinner time came and went. We reached
our hotel at about midnight and went to bed without food. And the next
day, neither of us wanted nor ate breakfast.
I ate lunch but without appetite and
very little pleasure. Partial then full appetite returned slowly after
24 hours.
The future
Mr Chennells is ecstatic:
"The San will finally throw off
thousands of years of oppression, poverty, social isolation and
discrimination.
"We will create trust funds with
their Hoodia royalties and the children will join South Africa's middle
classes in our lifetime.
"I envisage Hoodia cafes in London
and New York, salads will be served and the Hoodia cut like cucumber on
to the salad.
"It will need flavouring to
counter its unpleasant taste, but if it has no side effects and no
cumulative side-effects."
Unfortunately for the overweight,
Hoodia will not be around for several years, the clinical trials still
have several years to run.
Do not travel to the Kalahari to steal
the plant as it is hard to find and illegal to export.
And beware internet sites offering
Hoodia "pills" from the US as we tested the leading brand and
discovered it has no discernible Hoodia in it.
So just be patient. Help is at hand.
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